PETs are frequently divided into two groups based on their functional status, but unfortunately there is no uniformly accepted definition of a functional PET. The origin of these tumors is not fully known, but they may arise from pluripotent cells within the exocrine pancreas ( Vortmeyer et al. Pancreatic endocrine tumors are generally more indolent than adenocarcinoma of the pancreas and have a better prognosis ( Carriaga & Henson 1995, Fesinmeyer et al. PETs comprise <3% of all pancreatic neoplasms ( Cubilla & Hajdu 1975, Carriaga & Henson 1995, Fesinmeyer et al. The incidence is higher in autopsy studies, ranging from 0.8 to 10% suggesting that these tumors frequently go unnoticed ( Grimelius et al. 1989, Carriaga & Henson 1995, Lam & Lo 1997, Halfdanarson et al. Pancreatic endocrine tumors (PETs) are uncommon neoplasms with an incidence of <1 per 100 000 person-years in population studies ( Moldow & Connelly 1968, Buchanan et al.
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March 2023
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